Developmental Immunology and Aging

The Richard and Kenneth Skodnek Laboratory

  • Shahaf G,1 Zisman-Rozen S1, Benhamou D, Melamed D2 and Mehr R2. (2016). B cell development in the bone marrow is regulated by homeostatic feedback exerted by mature B cells. Immunol. 7:77 1equal contribution, 2equal supervision.
  • Coffre , Benhamou D., Rieß D., Blumenberg L., Snetkova V., Hines M.J., Chakraborty T., Bajwa S., Jensen K., Chong M.M.W., Getu L., Silverman G.J., Blelloch R., Littman D.R., Melamed D., Skok J.A, Rajewsky K. and , Koralov S.B. (2016). miRNAs are essential for the regulation of the PI3K/AKT/FOXO pathway and receptor editing during B cell maturation. Cell Rep. 17:2271-2285.
  • Benhamou D., Labi V., Novak R., Dai I., Shafir-Alon S., Weiss A., Gaujoux R., Arnold R., Shen-Orr S.S., Rajewsky K. and Melamed D. (2016). A c-Myc/miR17-92/Pten axis controls PI3K-mediated positive and negative selection in B cell development and reconstitutes CD19 deficiency. Cell Rep. 16:419-431.
  • Benhamou D., Labi V., Getahun A., Benchetrit E., Dowery R., Rajewsky K., Cambier J.C., Melamed D. (2018). The c-Myc/miR17-92/PTEN axis tunes PI3K activity to control expression of recombination activating genes in early B cell development. Front Immunol. 9:2715.
  • Avivi I., Zisman-Rozen S., Naor S., Dai I., Benhamou D., Shahaf G., Tabibian-Keissar H., Rosenthal N., Rakovsky A., Hanna A., Shechter A., Peled E., Benyamini N., Dmitrukha E., Barshack I., Mehr R., and Melamed D. (2019). Depletion of B cells rejuvenates the peripheral B cell compartment but is insufficient to restore immune competence in aging. Aging Cell 6:e12959.
  • Labi V., Schoeler K. and Melamed D. (2019). miR-17~92 in lymphocyte development and lymphomagenesis. Cancer Lett. 446: 73-80.
  • Hines MJ, Coffre M, Mudianto T, Panduro M, Wigton EJ, Tegla C, Osorio-Vasquez V, Kageyama R, Benhamou D, Perez O, Bajwa S, McManus MT, Ansel KM, Melamed D, and Koralov SB. (2020). miR-29 Sustains B Cell Survival and Controls Terminal Differentiation via Regulation of PI3K Signaling. Cell Rep. 33: 108436.
  • Dowery R, Benhamou D, Benchetrit E, Harel O, Nevelsky A, Zisman-Rozen S, Braun-Moscovici Y, Balbir-Gurman A, Avivi I, Shechter A, Berdnik D, Wyss-Coray T, Melamed D. (2021). Peripheral B-cells repress B-cell regeneration in aging through a TNFα/IGFBP-1/IGF1 immune-endocrine axis. Blood. 2021012428