Melamed Laboratory for Developmental Immunology
The broad focus of the Melamed lab is the elucidation of mechanisms regulating generation of B lymphocytes and controlling their fate decisions. Life and death decisions in B lineage cells primarily depend on antigen receptor signaling, which is integrated by cytoplasmic signaling pathways to mediate differentiation, proliferation or apoptosis. We have discovered that alteration of antigen receptor signaling modifies cell fate decisions and competence for developmental progression. We further found that cell fate decision has a major role in regulating cellular homeostasis of B lineage cells.
Current research in the lab explores:
This laboratory is named for Richard and Kenneth Skodnek